B12 Smart Serum

Calms Redness & Sensitivity
Vitamin B12, Defensil® Plus and Holy Basil help soothe stressed skin and reduce the visible appearance of redness and irritation.

Strengthens the Skin Barrier
Ceramides, fatty acids, Niacinamide and L22® Lipid Complex help replenish the skin's protective lipid layers and improve resilience.

Supports the Skin Microbiome
SymReboot™, Repair Complex CLR and microbiome-supporting actives help support a more balanced skin environment, particularly when skin is reactive or easily disrupted.

Hydrates & Reduces Moisture Loss
Beta-Glucan and biomimetic lipids help improve hydration and reduce moisture loss, leaving skin feeling softer and more comfortable.

Supports Breakout-Prone Skin
A good option when breakouts are accompanied by inflammation, sensitivity or a compromised barrier rather than simply focusing on exfoliating the skin.

Antioxidant Protection
Lipochroman-6 and Proteolea help protect stressed skin against oxidative and environmental damage.

Vitamin B12 (Cyanocobalamin)
Helps calm visible redness and supports healthier barrier function in stressed and compromised skin.

Niacinamide (Vitamin B3)
Supports barrier function, hydration, oil regulation and the appearance of redness and uneven tone.

SK-Influx Ceramide Complex
A blend of ceramides and fatty acids designed to mimic the skin's own lipid structure, helping strengthen the barrier and improve moisture retention.

L22® Lipid Complex
Helps replenish skin-identical lipids, supporting hydration, elasticity and barrier resilience.

Beta-Glucan
A soothing, hydrating ingredient that helps reduce moisture loss and support the skin's natural defences.

Holy Basil + Defensil® Plus
Calming botanical actives that help reduce the appearance of irritation, inflammation and redness.

SymReboot™ + Repair Complex CLR
Help support the skin microbiome and restore balance to stressed and reactive skin.

• Sensitive or reactive skin

• Redness and inflammation

• Rosacea-prone skin

• Compromised or impaired skin barriers

• Irritated, stressed or imbalanced skin

• Acne and inflamed breakouts

• Dehydration associated with barrier impairment

• Skin struggling to tolerate stronger corrective products

• Anyone wanting a calming, multi-purpose serum

• Simplified or minimal skincare routines

Use morning and/or evening on freshly cleansed skin.

Apply 2–3 pumps over the face, neck and décolletage.

If using other serums, apply B12 Smart Serum after water or gel-based serums and before your moisturiser.

Serums are designed to deliver concentrated active ingredients to the skin to target specific concerns. While your cleanser and moisturiser support the overall health and function of your skin, a serum can add a more targeted step to your routine.

Depending on the ingredients, serums can help address concerns such as dehydration, pigmentation, breakouts, redness, oiliness and visible signs of ageing. They can also support the skin barrier and provide antioxidant protection.

Because serums are usually lightweight and formulated with a higher concentration of specific active ingredients, they can be an effective way to personalise your skincare routine around what your skin needs.

You don't necessarily need lots of serums either. The right one or two, chosen for your skin and concerns, can make a meaningful difference as part of a consistent routine.

Think of your serum as the targeted treatment step in your skincare routine — chosen to support your specific skin goals.

Professional Australian-made skincare focused on skin health, corrective care and long-term skin function.

O COSMEDICS combines skin science with functional active ingredients to create high-performance skincare designed to address a wide range of skin concerns while supporting the health of the skin barrier.

Skin First Philosophy

O COSMEDICS follows the principles of Corneotherapy, a skin treatment philosophy centred around protecting, repairing and maintaining the skin's outermost layer — the stratum corneum.

Rather than taking an aggressive approach to skincare, the range focuses on working with the skin's natural biology and supporting healthy skin function. Active ingredients and corrective treatments can then be introduced according to what the skin needs and can tolerate.

Functional Actives

O COSMEDICS products are formulated with functional doses of active ingredients selected for their ability to support specific skin functions and concerns.

These actives are used across the range to target concerns including pigmentation, acne, congestion, dehydration, inflammation, redness, loss of firmness and visible signs of ageing.

Science & Skin Health

O COSMEDICS takes a skin-health approach that considers more than just the visible appearance of the skin.

Its formulations are designed around key factors that influence skin ageing and function, including collagen breakdown, inflammation, glycation, photo damage and oxidation.

The range also incorporates biomimetic ingredients — ingredients designed to work in harmony with the skin's natural structure and processes — alongside O COSMEDICS' V8 Peptide Complex®.

Australian Made & Woman Owned

O COSMEDICS is proudly Australian made, with its products manufactured at its Sydney-based facility.

The brand was developed in Australia with the unique skin challenges of the Australian environment and climate in mind. O COSMEDICS was founded by Australian skin and beauty therapist Maria Enna-Cocciolone.

Professional Skincare

O COSMEDICS is used by professional skin therapists and clinics in Australia and internationally.

The range includes everyday skincare as well as more targeted corrective products, allowing routines to be tailored to different skin types, concerns and stages of skin health.

The goal is simple: support healthy skin, address individual concerns and achieve visible results without losing sight of the skin's long-term health.

B12 Smart Serum is particularly useful when the priority is to calm and strengthen the skin before pushing harder with corrective actives.

It can be a great choice for acne-prone skin that has become irritated from over-exfoliation, rosacea-prone or redness-prone skin, or anyone whose barrier feels like it just isn't coping.

Unlike a simple hydrating serum, it combines hydration, barrier lipids, calming ingredients and microbiome support in one product, making it a useful option for keeping routines simple.

Some skin may experience a temporary feeling of warmth or tingling when first applied. If this feels persistent or uncomfortable, stop use and check in before continuing.

• Free from parabens, sulfates, petrochemicals and mineral oils

• Free from artificial colours and harsh preservatives

• Free from harsh synthetic fragrances

• Vegan-friendly, gluten-free and cruelty-free

• Emulsifier-free

• Formulated with biomimetic ingredients designed to work in harmony with the skin's natural physiology

Water (Aqua), Caprylic/ Capric Triglyceride, Jojoba Oil/Macadamia Seed Oil Esters, Glycerin, Octyldodecanol, Niacinamide, Bifida Ferment Lysate, Propylene Glycol Caprylate, Cannabis Sativa Seed Oil, Ceramide NP, Ceramide AP, Ceramide EOP, Cyanocobalamin, Acetyl Octapeptide-3, Ziziphus Jujuba Seed Extract, Olea Europaea (Olive) Leaf Extract, Cardiospermum Halicacabum Flower/Leaf/Vine Extract, Lactobacillus Ferment, Hydrolyzed Jojoba Esters, Ribes Nigrum (Black Currant) Seed Oil, Helianthus Annuus (Sunflower) Seed Oil, Rosmarinus Officinalis (Rosemary) Leaf Extract, Ocimum Sanctum Leaf Extract, Dimethylmethoxy Chromanol, Phytosphingosine, Beta-Glucan, Cholesterol, Behenic Acid, Polyglyceryl-10 Stearate, Polyglyceryl-6 Behenate, Cetearyl Alcohol, Glyceryl Stearate, Sodium Cetearyl Sulfate, Triethyl Citrate, Sodium Levulinate, Caprylyl Glycol, Behenyl Alcohol, Glyceryl Behenate, Lecithin, Cetearyl Glucoside, Acetic Acid, Lactic Acid, Phytic Acid, Ascorbic Acid, Cyamopsis Tetragonoloba (Guar) Gum, Xanthan Gum, Sphingomonas Ferment Extract, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Disodium EDTA, Squalene, Phytosteryl Macadamiate, Phytosterols, Maltodextrin, Sorbitan Oleate, Fructan, Tocopherol, Isohexadecane, Benzoic Acid, Decyl Glucoside, Phenoxyethanol, Sodium Benzoate, 1,2-Hexanediol, Pentylene Glycol, Polysorbate 80, Phenethyl Alcohol, Sodium Hydroxide, Citric Acid.